EDGE-TO-EDGE REPAIR (TEER)
MitraClip™ is the first minimally invasive TEER* therapy that delivers a life-changing treatment option for selected patients with Primary Mitral Regurgitation (PMR) or Secondary Mitral Regurgitation (SMR) who would otherwise go untreated.1,2 MitraClip™ is the standard of care in TMVr built on proven mitral valve therapy with over 20 years of experience, an extensive body of clinical evidence, and more than 200,000 patients treated worldwide.3
TAILORED. OPTIMIZED. PROVEN. MITRACLIP™ G4
MitraClip™ TEER system’s dedicated design for the mitral anatomy optimizes navigation for consistent clinical results. Its proven performance and tailored treatment options allow it to treat the broadest range of mitral anatomies.
MitraClip™ G4 now offers four Clip sizes to help tailor repair based on patient mitral valve anatomy.
- G4 NT is the original MitraClip™ NT/NTR Clip size.
- G4 XT is the equivalent of XTR, with Clip arms that are 3mm longer than G4 NT and allow for easier grasping due to better reach.**
The G4 NTW and XTW clips have a 50% wider grasping area than the NT and XT clips respectively. They are designed to further reduce regurgitant volume of MR with the implantation of a single clip.**
MITRACLIP™ SUCCESSFULLY TREATS A BROAD RANGE OF VALVE ANATOMIES IN REAL-WORLD USE8,9
NEARLY 1 IN 5 PATIENTS TREATED HAVE VALVE ANATOMIES CONSIDERED COMPLEX8
Valve anatomies include: presence of severely degenerative leaflets, wide flail gaps or widths, calcified landing zone, wide jet, primary jet outside of A2/P2, and more.8
Long arm clip use was associated with improved MR reduction for severe
baseline MR, smaller annular dimensions, larger prolapse gaps and complex
mitral valve anatomy in PMR.
Cardiac Surgeon with over 10 years of experience with MitraClip™*
CLIP SELECTION RECOMMENDATIONS BASED ON MITRAL VALVE ANATOMY7,8**
Valve anatomies include: presence of severely degenerative leaflets, wide flail gaps or widths, calcified landing zone, wide jet, primary jet outside of A2/P2, and more.8
| CLIP SELECTION CONSIDERATIONS | FAVORS G4 NTW | FAVORS G4 NT | FAVORS G4 XTW | FAVORS G4 XT |
|---|---|---|---|---|
| Leaflet Length < 9mm | • | • | ||
| Leaflet Length ≥ 9mm | • | • | ||
| Broad Jet | • | • | ||
| Smaller Valve | • | |||
| Larger Valve | • | • | • |
MitraClip™ G4 clip selection recommendations are based on the clinical experience of physicians. The EXPAND G4 observational study evaluates adherence to clip size selection recommendations and their associated outcomes.
CGA provides the option to grasp leaflets simultaneously or independently, enabling the ability to confirm and optimize leaflet grasp.
The innovative clip delivery system is a highly manoeuvrable delivery catheter that is used to implant the MitraClip™ via a steerable guide catheter.
PRECISION AND CONTROL FROM DELIVERY SYSTEM SPECIFICALLY DESIGNED FOR THE MITRAL VALVE**
IN OUR INSTITUTE, WE HAVE NOW REDUCED DEVICE TIME TO ~20 MIN.
Echocardiographer with 6 years of MitraClip™ experience, commenting on MitraClip™ G4*
SIMPLIFIED PROCEDURAL STEPS1
- 40% reduction in system preparation steps
- Simplified system deployment with minimal number of steps
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*The testimonial does not provide any indication, guide, warranty or guarantee as to the response patients may have to the treatment or effectiveness of the product or therapy in discussion. Opinions about the treatment discussed can and do vary and are specific to the individual’s experience and might not be representative of others.
**Tests performed by and data on file at Abbott.
- MitraClip™ G4 System Instructions for Use.
- Lim DS, Reynolds MR, Feldman T, et al. Improved functional status and quality of life in prohibitive surgical risk patients with degenerative mitral regurgitation after the transcatheter mitral valve repair. J Am Coll Cardiol. 2014;64(2):182–192. doi.org/10.1016/j.jacc.2013.10.021.
- Data on file at Abbott.
- Heidenreich PA, Bozkurt B, Allen LA, et al. “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association. Joint Committee on Clinical Practice Guidelines.” J Am Coll Cardiol. 2022;28(5):E1–E167. doi.org/10.1016/j.cardfail.2022.02.010.
- Mirabel M, Lung B, Baron G, et al. What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery? Eur Heart J. 2007;28(11):1358–1365. doi.org/10.1093/eurheartj/ehm001.
- Cioffi G, Tarantini L, De Feo S, et al. Functional mitral regurgitation predicts 1-year mortality in elderly patients with systolic chronic heart failure. Eur J Heart Fail. 2005;7(7):1112–1117. doi.org/10.1016/j.ejheart.2005.01.016.
- Rottbauer WD. Contemporary Clinical Outcomes with MitraClip™ (NTR/XTR) System: Core-lab Echo Results from +1000 Patient the Global EXPAND Study. Data presented at PCR 2020.
- Maisano F. Clip Selection Strategy and Outcomes with MitraClip™ (NTR/XTR): Evidence-Based Recommendations from the Global EXPAND Study. Data presented at PCR 2020.
- Rodriguez E. Contemporary Outcomes with the MitraClip™ G4 System: Preliminary Results based on the EXPAND G4 Study. Data presented at TCT 2021.
- Vahanian A, Beyersdorf F, Praz F, et al. ESC/EACTS Scientific Document Group, 2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS), Eur Heart J.2022;43(7):561–632, doi.org/10.1093/eurheartj/ehab395.
- Yeo KK, Tan JWC, Muller DW, et al. Asian Pacific Society of Cardiology Consensus Recommendations on the Use of MitraClip for Mitral Regurgitation. Eur Cardiol. 2021;16:e25. doi.org/10.15420/ecr.2021.01.
- McDonagh TA, Metra M, Adamo M, et al., ESC Scientific Document Group, 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC, Eur Heart J.2012; 42(36):3599–3726, doi.org/10.1093/eurheartj/ehab368.