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Mitral Regurgitation (MR) accounts for the vast majority of all mitral valve diseases.1 It has a prevalence of approximately 2% in the general population and is more common in the elderly population.3 Approximately 10% of people over the age of 70 have clinically meaningful MR.5

If left untreated, MR can lead to Heart Failure (HF), or deterioration of pre-existing HF, resulting in an increased number of hospital admissions and a substantial cost burden to health systems.6,8


Mitral Regurgitation (MR) occurs when the mitral valve leaflets fail to properly close during ventricular contraction (systole) so blood flows back into the left atrium, leading to inefficient pumping of blood around the body.9,18

Primary (e.g. degenerative or organic) Mitral Regurgitation (PMR) is caused by abnormalities in one or more components of the mitral valve architecture, such as the leaflets, chordae, or papillary muscles.10,11

Secondary Mitral Regurgitation (SMR), also referred to as Functional Mitral Regurgitation (FMR), occurs as a result of left ventricle dysfunction, which is typically caused by ischaemic heart disease or dilated cardiomyopathy. In SMR, the mitral valve is in itself normal.10,11


Two Types of Mitral Regurgitation


Primary MR

Secondary MR

Mitral regurgitation, if left untreated, initiates a cascade of events leading to HF and death12-14
*The 1-year mortality rate of 57% was recorded in a subgroup of patients with MR grade 4+.12


Treatment of MR is guided by the disease classification (primary/secondary) and severity. In SMR the approach to treatment is also guided by the nature of the patient’s underlying heart disease. The best treatment approach for a given patient and their condition (whether it be PMR or SMR) is determined by a Multidisciplinary Heart Team (MDT).16 Treatment options for MR include medical management, surgical repair or replacement, and Transcatheter Mitral Valve repair (TMVr) or Replacement (TMVR). Transcatheter Edge-to-Edge Repair (TEER) is a minimally invasive TMVr option.




Find out more



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